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OPC

In het kort
  • Oligomere proanthocyanidinen (OPC) zijn bioflavonoïden die onder andere te vinden zijn in druivenpitten.
  • OPC, ook wel druivenpitextract genoemd, is een krachtige antioxidant en kan ingezet worden bij oxidatieve stress.
  • Druivenpitextract werkt als antioxidant, schimmelwerend, antibacterieel en ontstekingsremmend.
  • Een onderhoudsdosering OPC uit druivenpitten is 50 – 100 mg per dag. Therapeutische doseringen lopen op tot 400 mg per dag.
  • Druivenpitextract kan onder andere ingezet worden bij hoge bloeddruk, artritis, cholesterol en wonden.
In het kort

Wat is OPC?

De afkorting OPC staat voor oligomere proanthocyanidinen. Deze bioflavonoïden zijn voornamelijk te vinden in druivenpitten, maar ook in de vrucht, bladeren en zaden van de druif. Druivenproducten bevatten fenolverbindingen, waaronder oligomere proanthocyanidinen (OPC’s), proanthocyanidinen, flavonolen en polyflavan-3-olen. Proanthocyanidinen zijn verantwoordelijk voor het produceren van de rode kleur van druiven.1 OPC, ook wel druivenpitextract genoemd, is een krachtige antioxidant.

Wat is OPC?

Gebruik

OPC kan onder andere toegepast worden bij oedeem, hart- en vaataandoeningen, huidveroudering, ontstekingen, allergieën, huidaandoeningen en oogziekten.

Gebruik

Veiligheid

Volwassenen

Druivenpitextract is waarschijnlijk veilig bij oraal gebruik in hoeveelheden die gewoonlijk in voedingsmiddelen worden aangetroffen. Druiven en extracten van druivenschillen hebben de GRAS-status in de VS, wat vertaalt naar ‘algemeen erkend als veilig’.88

Mogelijk veilig wanneer de hele vrucht van de druif, of extracten van de vrucht, het zaad of het blad, oraal en op de juiste manier in medicinale hoeveelheden worden gebruikt. Druivenpitextracten zijn schijnbaar veilig gebruikt in dagelijkse doseringen tot 200 mg gedurende maximaal 11 maanden en in dagelijkse doseringen tot 2000 mg gedurende maximaal drie maanden.8,89,90,91

Crèmes en zalven die twee of vijf procent druivenpitextract bevatten zijn tot drie weken topisch gebruikt met schijnbare veiligheid.87,92

Kinderen, zwangerschap en borstvoeding

Druivenpitextract is waarschijnlijk veilig bij oraal gebruik in hoeveelheden die normaal in voedingsmiddelen zit.

Veiligheid

Interacties

Medicijnen

Theoretisch kunnen druivenextracten antibloedplaatjeseffecten hebben en het risico op bloedingen verhogen als ze worden gebruikt met anticoagulantia of antibloedplaatjesgeneesmiddelen.64,93

Een kleine farmacokinetische studie bij gezonde jonge volwassenen toont aan dat de inname van 200 ml paars druivensap samen met ciclosporine de opname van het medicijn tot wel 30 procent kan verminderen in vergelijking met water.94

Theoretisch zou druivenpitextract de niveaus van verschillende substraten kunnen veranderen:

  • Verlagen van CYP1A2 waardoor de opname van fenacetine kan verlagen.95
  • Verhogen van CYP2D6.96
  • Verhogen van CYP2E1.97
  • Verhogen van CYP3A4 waardoor de eliminatie van midazolam kan verhogen.96

Kruiden/supplementen

In vitro bewijs suggereert dat druivenextracten de aggregatie van bloedplaatjes kunnen verminderen.64,93 In combinatie met andere kruiden/supplementen die bloedplaatjesaggregatieremmende effecten hebben kan dit aanvullende effecten hebben.

Interacties

Dosering

Volwassen – Oraal

Er zijn veel verschillende formuleringen gebruikt, waaronder hele druivenextracten, druivenpitextracten, druivenblad- of wijnstokextracten, druivensappen en druivenpulp.

Druivenpit- of hele druivenextracten die in klinisch onderzoek worden gebruikt, zijn meestal gestandaardiseerd op basis van het gehalte aan polyfenolen of proanthocyanidinen, een specifieke klasse polyfenolen.

Een gangbare dosering OPC’s uit druivenpitten is 50 – 100 mg per dag. Therapeutische doseringen rangeren van 150 tot 400 mg per dag.

Dosering
Referenties
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